Relation of Bone Marrow Findings to Serum Protein Changes in Lymphosarcoma, Chronic Lyinphocytic Leukemia and Hodgkin’s Disease

LTERATIONS in serum protein demonstrable by electrophoretic analysis have been noted fairly frequently in cases of lymphosarcoma, lymphocytic leukemia and Hodgkin’s disease. Abnormal proteins such as cryoglobulins and myeloma-type proteins also have been observed in the serum of an occasional patient with these conditions. in this study we attempted to determine whether disturbances in serum globulins are related to specific morphologic patterns in the bone marrow in cases of lymphosarcoma, chronic lymphocytic leukemia and Hodgkin’s disease. \Ve studied especially ( 1 ) the concurrent plasma cell reaction or absence of plasma cells anti ( 2 ) qualitative morphologic changes in lymphocytes in the sense of lvmphoid at pia.